Asymptomatic from all studies

## 
## Random-Effects Model (k = 32; tau^2 estimator: EB)
## 
## tau^2 (estimated amount of total heterogeneity): 0.009455 (SE = 0.003782)
## tau (square root of estimated tau^2 value):      0.097235
## I^2 (total heterogeneity / total variability):   90.25%
## H^2 (total variability / sampling variability):  10.25
## 
## Test for Heterogeneity:
## Q(df = 31) = 395.831093, p-val < .000001
## 
## Model Results:
## 
## estimate        se      zval      pval     ci.lb     ci.ub 
## 0.177613  0.021571  8.233893  <.000001  0.135335  0.219892  *** 
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
##        estimate   ci.lb   ci.ub 
## tau^2    0.0095  0.0044  0.0235 
## tau      0.0972  0.0664  0.1534 
## I^2(%)  90.2450 81.1941 95.8395 
## H^2     10.2512  5.3175 24.0355

## [1] 29
##  [1]  433  656   73  314  189  239 1675 2625 1656 2365 2668 2381 1223 1871 2302 1304 2099 2585 2303 1117 1753
## [22] 1749 1050 2098 1934 2062 1068 2569 1855

Asymptomatic from subset of studies

## 
## Random-Effects Model (k = 14; tau^2 estimator: EB)
## 
## tau^2 (estimated amount of total heterogeneity): 0.013474 (SE = 0.007218)
## tau (square root of estimated tau^2 value):      0.116076
## I^2 (total heterogeneity / total variability):   90.94%
## H^2 (total variability / sampling variability):  11.03
## 
## Test for Heterogeneity:
## Q(df = 13) = 108.172859, p-val < .000001
## 
## Model Results:
## 
## estimate        se      zval      pval     ci.lb     ci.ub 
## 0.210880  0.036255  5.816543  <.000001  0.139821  0.281939  *** 
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
##        estimate   ci.lb   ci.ub 
## tau^2    0.0135  0.0046  0.0570 
## tau      0.1161  0.0679  0.2387 
## I^2(%)  90.9372 77.4431 97.6983 
## H^2     11.0341  4.4332 43.4469

## [1] 14
##  [1]  433  656   73  189  239 1675 2365 2099 2303 1117 1753 2098 1934 2569

Severe from all studies

## Warning in rma(yi, vi, data = ies_sev, method = "EB", weighted = TRUE): Studies with NAs omitted from model
## fitting.
## 
## Random-Effects Model (k = 13; tau^2 estimator: EB)
## 
## tau^2 (estimated amount of total heterogeneity): 0.001325 (SE = 0.000697)
## tau (square root of estimated tau^2 value):      0.036403
## I^2 (total heterogeneity / total variability):   91.30%
## H^2 (total variability / sampling variability):  11.49
## 
## Test for Heterogeneity:
## Q(df = 12) = 55.881897, p-val < .000001
## 
## Model Results:
## 
## estimate        se      zval      pval     ci.lb     ci.ub 
## 0.037624  0.011458  3.283644  0.001025  0.015167  0.060082  ** 
## 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
##        estimate   ci.lb   ci.ub 
## tau^2    0.0013  0.0003  0.0049 
## tau      0.0364  0.0184  0.0698 
## I^2(%)  91.2986 72.8281 97.4728 
## H^2     11.4924  3.6803 39.5692

## [1] 13
##  [1]  433  656  314 1656 1871 1304 2585 2303 1117 1753 1068 2569 1855